Adenylate kinase uses AMP metabolic signals produced or
downregulated during exercise, stress response, food consumption, hormone
changes.
Adenylate kinase relays
deliver AMP signals to metabolic sensors. It facilitates decoding of cellular information
by catalyzing nucleotide exchange in the intimate “sensing zone” of metabolic
sensors.
Through a chain of sequential reactions,
Adenylate kinase facilitates transfer
and utilization of γ- and β-phosphoryls in the ATP molecule.
Adenylate kinase reads the cellular energy state, generates,
tunes, and communicates AMP signals to metabolic sensors. In this way,
Adenylate kinase is able to convey
information about the overall energy balance. AMP-sensors inhibit ATP
consumption and promote ATP production.
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